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Effects of Other Medication on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (key route) and CYP2C9 (small route). Consequently, inhibitors of these isoenzymes may perhaps cut down sildenafil clearance and inducers of these isoenzymes might improve sildenafil clearance.More info is necessary to know if Viagra is Risk-free or helpfu